FREE Webinar: Effective Drug Distribution, Determination and Visualisation
Tuesday, September 28, 2010 - Tuesday, September 28, 2010
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Are you involved in CNS drug discovery or are you trying to minimise CNS side effects? Would you like to be able to visualise where your compound is distributed in a tissue without the time and expense of radiolabelling? Come and hear what NiKem Research scientists have to say about:
• the power of estimating free CNS drug exposures as part of your lead optimisation strategy;
• mass spectrometric imaging for visualising your compounds, their metabolites and biomarkers.
Over the last few years there has been increasing recognition that determining free drug concentrations and not total drug concentrations at or close to the site of action is a key element in predicting compound efficacy. Understanding the factors driving compound free fraction and consequently the free concentration has therefore become an essential part of a lead optimisation strategy. This seminar will highlight just some of the uses that can be made of brain tissue binding and derived free concentrations in designing compounds for CNS targets and conversely reducing the risk of unwanted CNS side effects. Translation of tissue binding to man will also be discussed.
Mass spectrometry continues to extend its role in drug discovery with the recent development of MALDI/TOF/TOF for simultaneous imaging of distribution in tissues of not only a small molecule but also its metabolites and protein biomarkers. This powerful technique will be reviewed with some examples from NiKem’s labs.
This webinar will benefit all those who are involved in lead optimisation drug discovery activities.
NiKem Research http://www.nikemresearch.com/ is a fully integrated drug discovery service provider offering synthetic and medicinal chemistry, ADMET/PK, in vitro pharmacology non GLP toxicology and GLP and GCP Bioanalysis. Our highly experienced team have a track record of success in progressing our clients research programmes.
Further Information: http://www.nikemresearch.com